Prostaglandin D Synthase Inhibitor Screening Assay Kit - 96 Well

Prostaglandin D2 (PGD2) is synthesized by two distinct types of prostaglandin D synthase (PGDS), the lipocalin-type (L-PGDS) enzyme and the hematopoietic (H-PGDS) enzyme. PGD2 is produced by H-PGDS in large quantities by allergen-stimulated mast cells and acts as a pro-inflammatory mediator in allergic reactions. Selective inhibition of H-PGDS is therefore being pursued as a drug target for allergy treatment. The Cayman Chemical PGDS Inhibitor Screening Assay Kit is a complete package for the evaluation of PGDS isozyme-specific inhibitors. Each kit includes highly purified H-PGDS and L-PGDS, as well as PGH2 which serves as the enzyme substrate. A complete enzyme immunoassay (EIA) for the direct quantification of PGD2 quantification without prior methoximation is included in the kit.Application/Inhibitor Screening Assay, Chemical Class/Assay Kits, Chemical Class/Eicosanoids, Chemical Class/Prostaglandins, Research Area/Allergy/Asthma, Research Area/Drug Discovery, Research Area/InflammationSynonyms :PGDS Inhibitor Screening Assay Kit